Published on Tuesday July 17, 2007
A user proposal titled "Mechanics and Materials Approach to Quantitative Assessment of Bone Quality" submitted jointly by Dr. Kalidindi, Dr. Goldman and Ph.D. student Mr. Pathak to the Center for Integrated Nanotechnologies (CINT) has been accepted as a CINT user project. The Center for Integrated Nanotechnologies is a Department of Energy, Basic Energy Sciences (DOE/BES) Nanoscale Science Research Center (NSRC) jointly operated by Los Alamos and Sandia National Laboratories. Through its core facility in Albuquerque with gateways to both Los Alamos and Sandia national laboratories, CINT provides open access to tools and expertise needed to explore the continuum from scientific discovery to the integration of nanostructures into the micro- and macro world.
This approved project will enable Pathak to visit the CINT facility at Los Alamos National Lab in order to do research on bone quality in collaboration with CINT scientists Dr. Greg Swadener and Dr. Amit Misra. The proposal focuses on the use of a combined experimental-modeling study of bone which involves characterization of the local mechanical properties of bone using dynamic nanoindentation measurements. This type of approach in bone can be used to quantify the dependence of the indentation properties to the local mineral composition and orientation. This will help tremendously in developing an understanding of the complex interactions between the different local state variables involved and how they influence the local mechanical properties. Dr. Kalidindi, Dr. Goldman and Pathak are performing research that marks a crucial first step in the formulation of a rigorous framework for establishing structure-property linkages in bone.