Published on Monday August 3, 2009
Professor Michele Marcolongo is the recipient of five new grants.
The National Science Foundation's (NSF) division of Biomedical Engineering has awarded Marcolongo (PI) and colleagues with a $309,000 grant titled "Modeling L-selectin mediated attachment strength during embryo implantation." The grant is aimed at quantifying the primary and secondary biomechanical interactions of a model blastocyst with the uterine endometrial epithelium to better understand conditions necessary for implantation of the blastocyst in the uterus. This work will be performed entirely at Drexel University through a collaboration with Ken Barbee, Ph.D., Biomedical Engineering and Noreen Robertson, D.D.S., Monika Jost, Ph.D., and Karen Berkowitz, M.D. from the Drexel College of Medicine. The collaboration was begun under a Women's Leadership Grant and continued with a grant from the State of PA through the medical school.
Synthes Spine of West Chester, PA has awarded $180,000 to Marcolongo (PI) for "The Role of Implant Bonding in the Retention of the Nucleus Replacement Device." This single investigator grant will investigate the interactions of the native nucleus pulposus and annulus fibrosus of the intervertebral disc through experimental testing and numerical modeling. These findings will be extended to nucleus replacement devices for the treatment of intervertebral disc-related lower back pain.
A collaboration with Marco Cannella, Ph.D. of Rehabilitation Sciences has received $120,000 in funding from the Department of Defense for the "Effect of Mechanical Impact on Intervertebral Disc Mechanical Behavior." This research work aims at understanding the effect of extreme impact conditions on the mechanical behavior and failure mechanisms of the intervertebral disc. Marcolongo serves as PI.
Additionally, Marcolongo has been granted a Coulter Foundation award for $100,000 to study the synthesis and characterization of a new family of biomimetic aggrecan molecules with Ken Barbee, Ph.D., Biomedical Engineering; Caroline Schauer, Ph.D., MSE; and Edward Vresilovic, M.D., Ph.D., Penn State Hershey Medical Center.
Finally, Marcolongo is a co-PI on a two-year $150,000 NSF Course, Curriculum and Laboratory Improvement grant for "Smart Biomaterials for Tissue Regenerative Engineering." PI on the grant is Dr. Elisabeth Papazoglou (Biomed) and other Co-PIs are Dr. Peter Lelkes (Biomed) and Dr. Anthony Lowman (Chemical and Biological Engineering).